Assessing Diagnostic Accuracy of Serum Holotranscobalamin (Energetic-B12) in Comparability with Different Markers of Vitamin B12 Deficiency
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About 15-40% India is Vitamin B12 poor (generally identified by whole Vitamin B12) however, as solely holoTC (lively kind) is taken up by physique cells, thus measuring holoTC is extra reflective of Vitamin B12 standing than the previous. We aimed to evaluate diagnostic accuracy of serum holoTC in comparison with whole Vitamin B12 and whole Homocysteine (HCY) as indicator of serum Vitamin B12 standing. 217 human topics (99 males and 118 females) starting from 17 to 83 years had been divided into Vitamin B12 poor (n = 70), borderline (n = 100) and sufficient teams (n = 47) who had been further assessed for markers of Vitamin B12 deficiency-holoTC, HCY, Imply Corpuscular Quantity (MCV), Folate, heamoglobin and creatinine.
-
A robust optimistic correlation was discovered between Complete Vitamin B12 and holoTC (r = 0.754, p = <0.001) however robust adverse correlation existed between holoTC and HCY (r = – 0.471, p = <0.001). Concordance between Complete Vit B12 and HCY (Kappa index = 0.51, p < 0.001); between holoTC and HCY (Kappa index = 0.52, p = <0.001) had been statically vital however the latter had a greater sensitivity and specificity.
DKK-1 (HEK293-expressed), Human | Human DKK-1 ELISA package
-
Additionally, statically vital affiliation exists between Complete Vitamin B12 and holoTC with HCY (p = <0.001). Due to this fact, it’s ascertained that Energetic Vitamin B12 assay is a better check and will be thought-about as an early marker of vitamin B12 deficiency.
Key phrases: Energetic vitamin B12; Holotranscobalamin (holoTC); Homocystine (HCY); Vitamin B12; Vitamin B12 deficiency.
, Human) DKK-1 (HEK293-expressed), Human |
| HY-P7155A |
MedChemExpress |
50ug |
EUR 843.00 |
 Recombinant Human DKK-1 Protein |
| PROTO94907-3 |
BosterBio |
10ug |
EUR 317.00 |
 Human DKK-1 ELISA kit |
| LF-EK50797 |
Abfrontier |
1×96T |
EUR 648.00 |
 Dkk-1 Polyclonal Antibody |
| ES4292-100ul |
ELK Biotech |
100ul |
EUR 279.00 |
Dkk-1 Polyclonal Antibody |
| ES4292-50ul |
ELK Biotech |
50ul |
EUR 207.00 |
Dkk-1 Polyclonal Antibody |
| ABP53293-003ml |
Abbkine |
0.03ml |
EUR 158.00 |
- Immunogen information: Synthesized peptide derived from the C-terminal region of human Dkk-1
- Applications tips:
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Dkk-1 Polyclonal Antibody |
| ABP53293-01ml |
Abbkine |
0.1ml |
EUR 289.00 |
- Immunogen information: Synthesized peptide derived from the C-terminal region of human Dkk-1
- Applications tips:
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Dkk-1 Polyclonal Antibody |
| ABP53293-02ml |
Abbkine |
0.2ml |
EUR 414.00 |
- Immunogen information: Synthesized peptide derived from the C-terminal region of human Dkk-1
- Applications tips:
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Dkk-1 Polyclonal Antibody |
| 41928-100ul |
SAB |
100ul |
EUR 252.00 |
Dkk-1 Polyclonal Antibody |
| 41928-50ul |
SAB |
50ul |
EUR 187.00 |
 Human CellExp? DKK-1, Human Recombinant |
| 7132-10 |
Biovision |
|
EUR 278.00 |
Human CellExp? DKK-1, Human Recombinant |
| 7132-50 |
Biovision |
|
EUR 1132.00 |
 ELISA kit for Human DKK-1 |
| EK5390 |
SAB |
96 tests |
EUR 553.00 |
 Human DKK-1 PicoKine ELISA Kit |
| EK0867 |
BosterBio |
96 wells |
EUR 425.00 |
 Dkk-1 Polyclonal Conjugated Antibody |
| C41928 |
SAB |
100ul |
EUR 397.00 |
 Recombinant Mouse Dkk-1 Protein |
| RP01062 |
Abclonal |
5 μg |
EUR 183.00 |
) Human DKK-1 ELISA kit (4×96T) |
| LF-EK50798 |
Abfrontier |
4×96T |
EUR 2201.00 |
 Dkk-3 antibody |
| 22898-100ul |
SAB |
100ul |
EUR 390.00 |
 Recombinant Human Dkk-3 Protein |
| RP00355 |
Abclonal |
10 μg |
EUR 164.00 |
 ELISA kit for Rat DKK-1 |
| EK5668 |
SAB |
96 tests |
EUR 553.00 |
 ELISA Kit) Human DKK-1(Dickkopf-related protein 1) ELISA Kit |
| EH0113 |
FN Test |
96T |
EUR 524.10 |
- Detection range: 31.25-2000 pg/ml
- Uniprot ID: O94907
- Alias: DKK1/dickkopf(Xenopus laevis) homolog 1/dickkopf homolog 1(Xenopus laevis)/dickkopf related protein-1/Dickkopf-1/dickkopf-related protein 1/Dkk-1/DKK-1/SKdickkopf-1 like
|
 Dkk-3 Polyclonal Antibody |
| ES5541-100ul |
ELK Biotech |
100ul |
EUR 279.00 |
Dkk-3 Polyclonal Antibody |
| ES5541-50ul |
ELK Biotech |
50ul |
EUR 207.00 |
Dkk-3 Polyclonal Antibody |
| ABP54542-003ml |
Abbkine |
0.03ml |
EUR 158.00 |
- Immunogen information: Synthesized peptide derived from the Internal region of human Dkk-3 at AA rangle: 80-160
- Applications tips:
|
Dkk-3 Polyclonal Antibody |
| ABP54542-01ml |
Abbkine |
0.1ml |
EUR 289.00 |
- Immunogen information: Synthesized peptide derived from the Internal region of human Dkk-3 at AA rangle: 80-160
- Applications tips:
|
Dkk-3 Polyclonal Antibody |
| ABP54542-02ml |
Abbkine |
0.2ml |
EUR 414.00 |
- Immunogen information: Synthesized peptide derived from the Internal region of human Dkk-3 at AA rangle: 80-160
- Applications tips:
|
 Human DKK-4 PicoKine ELISA Kit |
| EK0868 |
BosterBio |
96 wells |
EUR 455.00 |
 Human DKK-3 PicoKine ELISA Kit |
| EK1323 |
BosterBio |
96 wells |
EUR 425.00 |
 Recombinant Human Dkk-3/DKK3 Protein |
| RP00209 |
Abclonal |
10 μg |
EUR 155.00 |
 [Fc]) Recombinant Dkk-1 Protein (Thr 32-His 266) [Fc] |
| VAng-1451Lsx-100g |
Creative Biolabs |
100 µg |
EUR 848.00 |
Recombinant Dkk-1 Protein (Thr 32-His 266) [Fc] |
| VAng-1451Lsx-1mg |
Creative Biolabs |
1 mg |
EUR 4724.00 |
 [His]) Recombinant Dkk-1 Protein (Thr 32-His 266) [His] |
| VAng-1453Lsx-100g |
Creative Biolabs |
100 µg |
EUR 1013.00 |
Recombinant Dkk-1 Protein (Thr 32-His 266) [His] |
| VAng-1453Lsx-1mg |
Creative Biolabs |
1 mg |
EUR 4999.00 |
 [Strep]) Recombinant Dkk-1 Protein (Thr 32-His 266) [Strep] |
| VAng-1454Lsx-1mg |
Creative Biolabs |
1 mg |
EUR 6374.00 |
Recombinant Dkk-1 Protein (Thr 32-His 266) [Strep] |
| VAng-1454Lsx-250g |
Creative Biolabs |
250 µg |
EUR 2470.00 |
Recombinant Dkk-1 Protein (Thr 32-His 266) [Strep] |
| VAng-1454Lsx-25g |
Creative Biolabs |
25 µg |
EUR 765.00 |
 [His]) Recombinant Dkk-1 Protein (Thr 32-His 272) [His] |
| VAng-1455Lsx-500g |
Creative Biolabs |
500 µg |
EUR 4449.00 |
Recombinant Dkk-1 Protein (Thr 32-His 272) [His] |
| VAng-1455Lsx-50g |
Creative Biolabs |
50 µg |
EUR 1013.00 |
 [Fc] [Avi]) Recombinant Dkk-1 Protein (Thr 32-His 266) [Fc] [Avi] |
| VAng-1452Lsx-200g |
Creative Biolabs |
200 µg |
EUR 3844.00 |
Recombinant Dkk-1 Protein (Thr 32-His 266) [Fc] [Avi] |
| VAng-1452Lsx-25g |
Creative Biolabs |
25 µg |
EUR 1013.00 |
 ELISA Kit) Human DKK-3(Dickkopf-related protein 3) ELISA Kit |
| EH0114 |
FN Test |
96T |
EUR 567.60 |
- Detection range: 62.5-4000 pg/ml
- Uniprot ID: Q9UBP4
- Alias: DKK-3/Dickkopf-3/Dkk3/REIC
|
 [His]) Recombinant Dkk-3 Protein (Pro 23-Ile 349) [His] |
| VAng-1456Lsx-1mg |
Creative Biolabs |
1 mg |
EUR 5494.00 |
Recombinant Dkk-3 Protein (Pro 23-Ile 349) [His] |
| VAng-1456Lsx-50g |
Creative Biolabs |
50 µg |
EUR 848.00 |
 [His]) Recombinant Dkk-3 Protein (Pro 23-Ile 350) [His] |
| VAng-1457Lsx-200g |
Creative Biolabs |
200 µg |
EUR 1123.00 |
Recombinant Dkk-3 Protein (Pro 23-Ile 350) [His] |
| VAng-1457Lsx-20g |
Creative Biolabs |
20 µg |
EUR 380.00 |
) Hemokinin 1 (human) |
| B5318-1 |
ApexBio |
1 mg |
EUR 340.00 |
, amide, human) Endothelin-1 (1-15), amide, human |
| A1111-1 |
ApexBio |
1 mg |
EUR 722.00 |
 Human Plasma) Haptoglobin, (Phenotype 1-1) Human Plasma |
| 7536-1 |
Biovision |
|
EUR 321.00 |
) Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His) |
| CC49-10ug |
Novoprotein |
10ug |
EUR 156.00 |
Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His) |
| CC49-1mg |
Novoprotein |
1mg |
EUR 2283.00 |
Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His) |
| CC49-500ug |
Novoprotein |
500ug |
EUR 1613.00 |
Recombinant Human Dickkopf-Related Protein 2/DKK-2 (N-Fc, C-6His) |
| CC49-50ug |
Novoprotein |
50ug |
EUR 369.00 |
, human) BNP (1-32), human |
| A1105-1 |
ApexBio |
1 mg |
EUR 177.00 |
 IGF-1, human recombinant |
| P1016-.1 |
ApexBio |
100 µg |
EUR 763.00 |
, human recombinant protein) Neuregulin/Heregulin-1? (NRG-1?/HRG-1?), human recombinant protein |
| P1054-1 |
ApexBio |
1 mg |
EUR 3947.00 |
 IL1RL1 Human, Interleukin-1 Receptor Like-1 Human Recombinant Protein, Sf9 |
| PROTQ01638-1 |
BosterBio |
Regular: 10ug |
EUR 317.00 |
 MMP-1 Matrix Metalloproteinase-1 Human Recombinant Protein |
| PROTP03956-1 |
BosterBio |
Regular: 20ug |
EUR 317.00 |
 PSG1 Human, Pregnancy Specific Beta-1-Glycoprotein 1 Human Recombinant Protein, Sf9 |
| PROTP11464-1 |
BosterBio |
Regular: 10ug |
EUR 317.00 |
 (human)) Amyloid ?-Peptide (1-42) (human) |
| B6057-.1 |
ApexBio |
100 ug |
EUR 276.00 |
 (human)) Parathyroid hormone (1-34) (human) |
| A1129-1 |
ApexBio |
1 mg |
EUR 166.00 |
 ApoA-1, human recombinant protein |
| P1052-.1 |
ApexBio |
100 µg |
EUR 313.00 |
ApoA-1, human recombinant protein |
| P1052-1 |
ApexBio |
1 mg |
EUR 1553.00 |
 WNT-1, human recombinant protein |
| P1068-1 |
ApexBio |
1 mg |
EUR 6940.00 |
 Recombinant Human Gremlin-1 Protein |
| PROTO60565-1 |
BosterBio |
50ug |
EUR 317.00 |
 ORM1 Orosomucoid 1 Human protein |
| PROTP02763-1 |
BosterBio |
Regular: 10ug |
EUR 317.00 |
 Recombinant Human Galectin-1 Protein |
| PROTP09382-1 |
BosterBio |
50ug |
EUR 317.00 |
 Recombinant Human PECAM-1 Protein |
| PROTP16284-1 |
BosterBio |
50ug |
EUR 317.00 |
 Recombinant Human ANG-1 Protein |
| PROTQ15389-1 |
BosterBio |
20ug |
EUR 317.00 |
 RAD51D (1-328 a.a.) Human Recombinant Protein) (1-328) RAD51D (1-328 a.a.) Human Recombinant Protein |
| PROTO75771-1 |
BosterBio |
Regular: 10ug |
EUR 317.00 |
Falsely optimistic fourth technology ADVIA Centaur® HIV Antigen/Antibody Combo assay within the presence of autoimmune hepatitis sort I (AIH)
- A 51-year-old lady was admitted to the hospital with abdominal ache, jaundice, and transaminitis. The affected person’s laboratory outcomes confirmed elevated liver enzymes, excessive antinuclear antibodies (ANA) titer, optimistic anti-smooth muscle antibody, and hypergammaglobulinemia.
- Given danger components for HIV an infection, an ADVIA Centaur® HIV Antigen/Antibody Combo assay was carried out exhibiting a reactive pattern with a observe up HIV-1 nucleic acid test (NAT) proving to be adverse.
Human CellExp? DKK-1, Human Recombinant
- Following affirmation of autoimmune hepatitis sort I through a liver biopsy, steroids had been initiated and vital medical enchancment of signs in addition to decision in transaminitis had been famous.
- Autoimmunity is the most certainly causative consider inducing a false optimistic reactive screening assay. You will need to acknowledge that cross-reactivity with autoimmune situations and HIV particular proteins is a possible concern for false reactive samples.
Recombinant Dkk-1 Protein (Thr 32-His 266) [Fc] [Avi]
Key phrases: ADIVA Centaur®; Autoimmune hepatitis; False optimistic HIV check; HIV antigen and antibody mixture check.
Goal: In our laboratory, 2.36% (6626/280765) samples obtained for insulin analysis have serum insulin concentrations increased than 300 mU/L, leading to curves exterior the linear vary within the insulin launch check (IRT). Accordingly, utilizing applicable dilution protocols to find out insulin focus precisely is important. Right here, we in contrast the effectiveness and financial system of 4 totally different options for diluting high-insulin serum in routine medical measurements.
Methodology: Residual serum samples with high-insulin concentrations starting from 200 to 300 mU/L had been collected in Peking Union Medical Faculty Hospital from August to November 2017. 4 totally different matrixes together with a Siemens original diluent, pure water, 0.9% NaCl, and low-insulin serum (labeled as A to D, respectively) were used to dilute the serum within the ratios of 1:2, 1:5, and 1:10.
 anti- Integrin alpha-5 antibody |
| FNab04347 |
FN Test |
100µg |
EUR 548.75 |
- Recommended dilution: WB: 1:500-1:2000
- Immunogen: integrin, alpha 5
- Uniprot ID: P08648
- Research Area: Stem Cells, Immunology, Cardiovascular, Cancer
|
 Anti-Integrin alpha 5/ITGA5 Antibody |
| A01911 |
BosterBio |
100ug/vial |
EUR 334.00 |
Anti-Integrin alpha 5/ITGA5 Antibody |
| PB9254 |
BosterBio |
100ug/vial |
EUR 294.00 |
 Alpha V Beta 5 Integrin, Peptide Aptamer, Biotinylated |
| AP-301-B |
Alpha Diagnostics |
1 mg |
Ask for price |
 Alpha V Beta 5 Integrin, Peptide Aptamer, unlabeled |
| AP-301-U |
Alpha Diagnostics |
5 mg |
Ask for price |
 Integrin alpha-5 Antibody |
| abx234347-100ug |
Abbexa |
100 ug |
EUR 509.00 |
- Shipped within 5-12 working days.
|
 Integrin alpha 5 Antibody |
| 49269-100ul |
SAB |
100ul |
EUR 333.00 |
Integrin alpha 5 Antibody |
| 49269-50ul |
SAB |
50ul |
EUR 239.00 |
 Anti-Integrin alpha 5 Rabbit Monoclonal Antibody |
| M01911 |
BosterBio |
100ug/vial |
EUR 397.00 |
 Alpha V Beta 5 Integrin, Peptide Aptamer, FITC labelled |
| AP-301-F |
Alpha Diagnostics |
1 mg |
Ask for price |
 Protein) Human Integrin Alpha 5 (ITGa5) Protein |
| 20-abx067272 |
Abbexa |
- EUR 662.00
- EUR 272.00
- EUR 2040.00
- EUR 787.00
- EUR 481.00
|
|
- Shipped within 5-7 working days.
|
 anti-Integrin beta 5 |
| YF-PA12792 |
Abfrontier |
100 ug |
EUR 403.00 |
anti-Integrin beta 5 |
| YF-PA24023 |
Abfrontier |
50 ul |
EUR 334.00 |
 Antibody) Integrin alpha 5 (CD49e) Antibody |
| AF5200 |
Affbiotech |
200ul |
EUR 304.00 |
 Integrin alpha 5 Conjugated Antibody |
| C49269 |
SAB |
100ul |
EUR 397.00 |
 Antibody) Integrin Alpha 5 (ITGA5) Antibody |
| 20-abx113185 |
Abbexa |
|
|
- Shipped within 5-10 working days.
|
 Antibody) Integrin Alpha 5 (ITGa5) Antibody |
| 20-abx129339 |
Abbexa |
- EUR 425.00
- EUR 133.00
- EUR 1177.00
- EUR 578.00
- EUR 328.00
|
|
- Shipped within 5-7 working days.
|
Integrin Alpha 5 (ITGA5) Antibody |
| 20-abx000873 |
Abbexa |
|
|
- Shipped within 5-10 working days.
|
Integrin Alpha 5 (ITGa5) Antibody |
| 20-abx101634 |
Abbexa |
- EUR 411.00
- EUR 133.00
- EUR 1149.00
- EUR 565.00
- EUR 314.00
|
|
- Shipped within 5-7 working days.
|
Integrin Alpha 5 (ITGa5) Antibody |
| 20-abx101635 |
Abbexa |
- EUR 467.00
- EUR 133.00
- EUR 1344.00
- EUR 634.00
- EUR 356.00
|
|
- Shipped within 5-7 working days.
|
Integrin Alpha 5 (ITGA5) Antibody |
| abx011678-100ul |
Abbexa |
100 ul |
EUR 411.00 |
- Shipped within 5-10 working days.
|
Integrin Alpha 5 (ITGA5) Antibody |
| 20-abx006811 |
Abbexa |
- EUR 411.00
- EUR 592.00
- EUR 182.00
- EUR 314.00
|
|
- Shipped within 5-10 working days.
|
Integrin Alpha 5 (ITGA5) Antibody |
| abx026655-400ul |
Abbexa |
400 ul |
EUR 523.00 |
- Shipped within 5-10 working days.
|
Integrin Alpha 5 (ITGA5) Antibody |
| abx026655-80l |
Abbexa |
80 µl |
EUR 286.00 |
- Shipped within 5-10 working days.
|
Integrin Alpha 5 (ITGa5) Antibody |
| 20-abx172956 |
Abbexa |
|
|
|
|
Integrin Alpha 5 (ITGA5) Antibody |
| 20-abx323564 |
Abbexa |
|
|
- Shipped within 5-10 working days.
|
Integrin Alpha 5 (ITGA5) Antibody |
| 20-abx325454 |
Abbexa |
|
|
- Shipped within 5-10 working days.
|
Integrin Alpha 5 (ITGA5) Antibody |
| 20-abx327245 |
Abbexa |
|
|
- Shipped within 5-10 working days.
|
 Antibody) Integrin alpha 5 (CD49e) Antibody |
| abx216264-100ug |
Abbexa |
100 ug |
EUR 439.00 |
- Shipped within 5-10 working days.
|
Integrin Alpha 5 (ITGA5) Antibody |
| 20-abx338742 |
Abbexa |
- EUR 411.00
- EUR 1845.00
- EUR 599.00
- EUR 182.00
- EUR 300.00
|
|
- Shipped within 5-10 working days.
|
Integrin Alpha 5 (ITGa5) Antibody |
| 20-abx179024 |
Abbexa |
|
|
|
|
 Integrin alpha 5 Rabbit mAb |
| A19069-100ul |
Abclonal |
100 ul |
EUR 410.00 |
Integrin alpha 5 Rabbit mAb |
| A19069-200ul |
Abclonal |
200 ul |
EUR 571.00 |
Integrin alpha 5 Rabbit mAb |
| A19069-20ul |
Abclonal |
20 ul |
EUR 221.00 |
Integrin alpha 5 Rabbit mAb |
| A19069-50ul |
Abclonal |
50 ul |
EUR 287.00 |
) Recombinant Integrin Alpha 5 (ITGa5) |
| 4-RPB287Bo01 |
Cloud-Clone |
- EUR 556.96
- EUR 252.00
- EUR 1813.60
- EUR 671.20
- EUR 1242.40
- EUR 436.00
- EUR 4384.00
|
|
- Uniprot ID: Q27977
- Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
- Form: Freeze-dried powder
- Predicted Molecular Mass (KD): 61.6kDa
- Isoelectric Point: 5.8
|
Recombinant Integrin Alpha 5 (ITGa5) |
| 4-RPB287Hu01 |
Cloud-Clone |
- EUR 476.32
- EUR 230.00
- EUR 1511.20
- EUR 570.40
- EUR 1040.80
- EUR 382.00
- EUR 3628.00
|
|
- Uniprot ID: P08648
- Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
- Form: Freeze-dried powder
- Predicted Molecular Mass (KD): 47.6kDa
- Isoelectric Point: 8.4
|
Recombinant Integrin Alpha 5 (ITGa5) |
| 4-RPB287Mu01 |
Cloud-Clone |
- EUR 476.32
- EUR 230.00
- EUR 1511.20
- EUR 570.40
- EUR 1040.80
- EUR 382.00
- EUR 3628.00
|
|
- Uniprot ID: P11688
- Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
- Form: Freeze-dried powder
- Predicted Molecular Mass (KD): 50.0kDa
- Isoelectric Point: 8.7
|
,antiserum #1) Rabbit Anti-Human Alpha Defensin 5 (NP-5),antiserum #1 |
| HDEFA51-S |
Alpha Diagnostics |
100 ul |
EUR 457.00 |
 anti-Integrin alpha 6 |
| YF-PA12761 |
Abfrontier |
50 ul |
EUR 363.00 |
anti-Integrin alpha 6 |
| YF-PA12762 |
Abfrontier |
100 ug |
EUR 403.00 |
 anti-Integrin alpha 1 |
| YF-PA12784 |
Abfrontier |
50 ug |
EUR 363.00 |
Outcomes: We discovered that the linear correlation coefficients of A to D had been increased than 0.9. The restoration charges of A to D had been 86.4%-104.0%, 73.2%-99.3%, 76.4%-101.3%, and 84.2%-99.7%, respectively. We conclude that using 0.9% NaCl, pure water, or low-insulin serum to dilute high-serum insulin (>300 mU/L) is possible and cost-effective.
Alpha V Beta 5 Integrin, Peptide Aptamer, FITC labelled
Conclusion: We suggest a dilution truthor of 1:5 on a Siemens ADVIA Centaur XP® instrument. The clinically reported vary was 0.5-1500 mU/L. For particular samples (>1500 mU/L), we beneficial utilizing low-insulin serum samples for dilution.
Key phrases: diluent; insulin; matrix; restoration.
, Mouse)
 : 96 Wells (OKAG00221))
 (OKBB00603))
