A Affected person with Berardinelli-Seip Syndrome, Novel AGPAT2 Splicesite Mutation and Concomitant Improvement of Non-diabetic Polyneuropathy
- Main polyneuropathy within the context of Seip-Berardinelli kind 1 seipinopathy, or congenital generalized lipodystrophy kind 1 (CGL1) has not been beforehand reported.
- We report the case historical past of a 27 yr outdated feminine CGL1 affected person presenting with an uncommon further growth of non-diabetic peripheral neuropathy and studying disabilities in early adolescence. Entire exome sequencing (WES) of the affected person genome recognized a novel variant, homozygous for a 52 bp intronic deletion within the AGPAT2 locus, coding for 1-acylglycerol-3-phosphate O-acyltransferase 2, which is uniquely related to CGL1 seipinopathies, with no molecular proof for twin analysis.
Mouse Leukemia Inhibitory Issue (LIF) ELISA Equipment
- Purposeful research utilizing RNA remoted from affected person peripheral blood leucocytes confirmed irregular RNA splicing ensuing within the lack of 25 amino acids from the affected person AGPAT2 protein coding sequence. Stability and transcription ranges for the misspliced AGPAT2 mRNA in our affected person nonetheless remained regular.
- Any AGPAT2 protein produced in our affected person is due to this fact more likely to be dysfunctional. Nonetheless, formal linkage of this deletion to the neuropathy noticed stays to be proven.
Anti-Apaf-1 (human) Monoclonal Antibody (2E12)
- The classical medical presentation of a affected person with AGPAT2-associated lipodystrophy reveals regular cognition and no growth of polyneuropathy. Cognitive disabilities and polyneuropathy are options related completely with medical CGL kind 2 arising from seipin (BSCL2) gene mutations. This case research means that in some genetic contexts, AGPAT2 mutations may also produce phenotypes with major polyneuropathy.
 ELISA Kit) Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DLR-LIF-Mu-48T | DL Develop | 48T | EUR 489.00 |
|
|||
Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DLR-LIF-Mu-96T | DL Develop | 96T | EUR 635.00 |
|
|||
Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DL-LIF-Mu-192 | DLdevelop | 1 kit of 192 tests | EUR 1079.00 |
Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DL-LIF-Mu-48 | DLdevelop | 1 kit of 48 tests | EUR 456.00 |
Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DL-LIF-Mu-96 | DLdevelop | 1 kit of 96 tests | EUR 609.00 |
Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| RD-LIF-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 489.00 |
Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| RD-LIF-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 677.00 |
Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| RDR-LIF-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 511.00 |
Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| RDR-LIF-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 709.00 |
 anti-LIF |
|||
| YF-PA12952 | Abfrontier | 50 ug | EUR 363.00 |
 Rabbit Polyclonal antibody Anti-CRBN |
|||
| Anti-CRBN | ImmunoStep | 50 µg | EUR 349.00 |
 Anti-LIF Antibody |
|||
| A01400 | BosterBio | 100ug/vial | EUR 294.00 |
 anti- LIF antibody |
|||
| LSMab09804 | Lifescience Market | 100 ug | EUR 386.00 |
anti- LIF antibody |
|||
| FNab09804 | FN Test | 100µg | EUR 548.75 |
|
|||
Anti-LIF Antibody |
|||
| PA1562 | BosterBio | 100ug/vial | EUR 294.00 |
Anti-LIF Antibody |
|||
| PB9036 | BosterBio | 100ug/vial | EUR 334.00 |
 Anti-LIF antibody |
|||
| STJ73631 | St John's Laboratory | 100 µg | EUR 359.00 |
Anti-LIF antibody |
|||
| STJ29846 | St John's Laboratory | 100 µl | EUR 277.00 |
Anti-LIF antibody |
|||
| STJ96472 | St John's Laboratory | 200 µl | EUR 197.00 |
 ELISA Kit) Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DLR-LIF-b-48T | DL Develop | 48T | EUR 547.00 |
|
|||
Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DLR-LIF-b-96T | DL Develop | 96T | EUR 715.00 |
|
|||
 ELISA Kit) Canine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DLR-LIF-c-48T | DL Develop | 48T | EUR 527.00 |
|
|||
Canine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DLR-LIF-c-96T | DL Develop | 96T | EUR 688.00 |
|
|||
 ELISA Kit) Human Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DLR-LIF-Hu-48T | DL Develop | 48T | EUR 380.00 |
|
|||
Human Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DLR-LIF-Hu-96T | DL Develop | 96T | EUR 485.00 |
|
|||
 ELISA Kit) Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DLR-LIF-p-48T | DL Develop | 48T | EUR 547.00 |
|
|||
Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DLR-LIF-p-96T | DL Develop | 96T | EUR 715.00 |
|
|||
 ELISA Kit) Rat Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DLR-LIF-Ra-48T | DL Develop | 48T | EUR 508.00 |
|
|||
Rat Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DLR-LIF-Ra-96T | DL Develop | 96T | EUR 661.00 |
|
|||
Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DL-LIF-b-192 | DLdevelop | 1 kit of 192 tests | EUR 1231.00 |
Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DL-LIF-b-48 | DLdevelop | 1 kit of 48 tests | EUR 510.00 |
Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DL-LIF-b-96 | DLdevelop | 1 kit of 96 tests | EUR 685.00 |
Canine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DL-LIF-c-192 | DLdevelop | 1 kit of 192 tests | EUR 1180.00 |
Canine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DL-LIF-c-48 | DLdevelop | 1 kit of 48 tests | EUR 492.00 |
Canine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DL-LIF-c-96 | DLdevelop | 1 kit of 96 tests | EUR 660.00 |
Human Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DL-LIF-Hu-192 | DLdevelop | 1 kit of 192 tests | EUR 795.00 |
Human Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DL-LIF-Hu-48 | DLdevelop | 1 kit of 48 tests | EUR 357.00 |
Human Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DL-LIF-Hu-96 | DLdevelop | 1 kit of 96 tests | EUR 467.00 |
Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DL-LIF-p-192 | DLdevelop | 1 kit of 192 tests | EUR 1231.00 |
Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DL-LIF-p-48 | DLdevelop | 1 kit of 48 tests | EUR 510.00 |
Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DL-LIF-p-96 | DLdevelop | 1 kit of 96 tests | EUR 685.00 |
Rat Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DL-LIF-Ra-192 | DLdevelop | 1 kit of 192 tests | EUR 1130.00 |
Rat Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DL-LIF-Ra-48 | DLdevelop | 1 kit of 48 tests | EUR 474.00 |
Rat Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| DL-LIF-Ra-96 | DLdevelop | 1 kit of 96 tests | EUR 635.00 |
Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| RD-LIF-b-48Tests | Reddot Biotech | 48 Tests | EUR 555.00 |
Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| RD-LIF-b-96Tests | Reddot Biotech | 96 Tests | EUR 771.00 |
Canine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| RD-LIF-c-48Tests | Reddot Biotech | 48 Tests | EUR 533.00 |
Canine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| RD-LIF-c-96Tests | Reddot Biotech | 96 Tests | EUR 740.00 |
Human Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| RD-LIF-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 367.00 |
Human Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| RD-LIF-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 502.00 |
Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| RD-LIF-p-48Tests | Reddot Biotech | 48 Tests | EUR 555.00 |
Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| RD-LIF-p-96Tests | Reddot Biotech | 96 Tests | EUR 771.00 |
Rat Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| RD-LIF-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 511.00 |
Rat Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| RD-LIF-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 709.00 |
Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| RDR-LIF-b-48Tests | Reddot Biotech | 48 Tests | EUR 580.00 |
Bovine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| RDR-LIF-b-96Tests | Reddot Biotech | 96 Tests | EUR 807.00 |
Canine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| RDR-LIF-c-48Tests | Reddot Biotech | 48 Tests | EUR 557.00 |
Canine Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| RDR-LIF-c-96Tests | Reddot Biotech | 96 Tests | EUR 774.00 |
Human Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| RDR-LIF-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 383.00 |
Human Leukemia Inhibitory Factor (LIF) ELISA Kit |
|||
| RDR-LIF-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 525.00 |
Novel Design of Eco-Pleasant Tremendous Elastomer Supplies With Optimized Arduous Segments Micro-Construction: Towards Subsequent-Technology Excessive-Efficiency Tires.
- Not too long ago, sustainable growth has develop into a major concern globally, and the power disaster is among the prime priorities. From the attitude of the commercial software of polymeric supplies, rubber tires are critically necessary in our each day lives. Nonetheless, the power consumption of tires can attain 6% of the world’s whole power consumption each year.
- In the meantime, it’s calculated that round 5% of carbon dioxide comes from the emission of tire rolling as a consequence of power consumption. To beat these extreme power and environmental challenges, designing and growing a high-performance fuel-saving tire is of paramount significance. Herein, a next-generation, eco-friendly tremendous elastomer materials based mostly on macromolecular meeting expertise has been fabricated.
AXMIR-1 RNA oligo anti-miRNA-1-3p with Xmotif
- Hydroxyl-terminated solution-polymerized styrene-butadiene rubber (HTSSBR) with excessive vinyl contents ready by anionic polymerization is used as versatile tender segments to acquire glorious moist skid resistance. Moreover, extremely symmetrical 1,5-naphthalene diisocyanate (NDI), completely different proportions of chain extender, and the cross-linking agent with average molecular size are chosen as inflexible laborious segments to realize simultaneous excessive warmth resistance.
- By way of this strategy, a homogeneous community supported by uniformly distributed laborious section nanoparticles is fashioned as a result of tender segments with equal size are chemically end-linked by the laborious segments. This super elastomer materials displays glorious put on resistance and low rolling resistance.
Anti-Cytokeratin 1 Rabbit Monoclonal Antibody
- Extra importantly, the wear and tear resistance, rolling resistance, and wet-skid resistance are diminished by 85.4, 42.3, and 20.8%, respectively, in comparison with the elastomeric materials conventionally used for tire. By profiting from this glorious complete service efficiency, the long-standing problem of the “magic triangle” plaguing the rubber tire business for nearly 100 years is resolved. It’s anticipated that this newly designed and fabricated elastomeric materials tailor-made for tires will develop into the subsequent era product, which may exhibit excessive potential for considerably reducing the gas consumption and decreasing the emission of carbon dioxide.
 Polyclonal Goat anti-GST α-form |
|||
| GST-ANTI-1 | Detroit R&D | 50 uL | EUR 280.00 |
 Anti-ALK Rabbit Monoclonal Antibody, Clone#RM361 |
|||
| M00301-1 | BosterBio | 100uL | EUR 385.00 |
 Anti-PARP-1 Antibody |
|||
| A00122-1 | BosterBio | 100ul | EUR 397.00 |
 Anti-Presenilin 1 Antibody |
|||
| A00138-1 | BosterBio | 100ul | EUR 397.00 |
 Anti-PAI-1 Antibody |
|||
| A00637-1 | BosterBio | 100ul | EUR 397.00 |
 Anti-Flk-1 Antibody |
|||
| A00901-1 | BosterBio | 100ul | EUR 397.00 |
 Anti-EDG-1 Antibody |
|||
| A01502-1 | BosterBio | 100ul | EUR 397.00 |
 Anti-ROBO-1 Antibody |
|||
| A01530-1 | BosterBio | 100ug | EUR 455.00 |
 Anti-Bag-1 Antibody |
|||
| A02423-1 | BosterBio | 50 ul | EUR 397.00 |
 Anti-TUB 1 Antibody |
|||
| A02917-1 | BosterBio | 100ug/vial | EUR 294.00 |
 Anti-Dok-1 Antibody |
|||
| A03039-1 | BosterBio | 100ul | EUR 397.00 |
 Anti-Cerebellin 1 Antibody |
|||
| A09176-1 | BosterBio | 100ul | EUR 397.00 |
 Anti-DOC-1 Antibody |
|||
| A09467-1 | BosterBio | 100ul | EUR 397.00 |
 Anti-TFIIIB90-1 Antibody |
|||
| A03761-1 | BosterBio | 100ul | EUR 397.00 |
 Anti-Atrophin-1 Antibody |
|||
| A03828-1 | BosterBio | 100ul | EUR 397.00 |
 Anti-CNG-1 Antibody |
|||
| A05494-1 | BosterBio | 100ul | EUR 397.00 |
 Anti-NPDC-1 Antibody |
|||
| A12846-1 | BosterBio | 100ul | EUR 397.00 |
 Anti-Periphilin 1 Antibody |
|||
| A06996-1 | BosterBio | 100ul | EUR 397.00 |
 Anti-Lyl-1 Antibody |
|||
| A07491-1 | BosterBio | 100ul | EUR 397.00 |
 Anti-GLI-1 Antibody |
|||
| A07972-1 | BosterBio | 100ul | EUR 397.00 |
 Monoclonal Antibody (2E12)) Anti-Apaf-1 (human) Monoclonal Antibody (2E12) |
|||
| M00889-1 | BosterBio | 100ug | EUR 432.00 |
 Anti-ALK-1 antibody |
|||
| STJ91563 | St John's Laboratory | 200 µl | EUR 197.00 |
Anti-ALK-1 antibody |
|||
| STJ96547 | St John's Laboratory | 200 µl | EUR 197.00 |
) Anti-HO-1 Monoclonal Antibody (HO-1-2) |
|||
| M00253-1 | BosterBio | 1mg | EUR 397.00 |
 Anti-TNF Receptor 1 Antibody |
|||
| A00294-1 | BosterBio | 200ug | EUR 522.00 |
 Anti-Galectin 1/Lgals1 Antibody |
|||
| A00470-1 | BosterBio | 100ug/vial | EUR 334.00 |
 Anti-LOX-1/OLR1 Antibody |
|||
| A00760-1 | BosterBio | 100ug/vial | EUR 294.00 |
 Anti-Syndecan-1/SDC1 Antibody |
|||
| A00991-1 | BosterBio | 100ug/vial | EUR 294.00 |
 Anti-IRAK-1/IRAK1 Antibody |
|||
| A01021-1 | BosterBio | 100ug/vial | EUR 334.00 |
 Anti-Neurexin 1/NRXN1 Antibody |
|||
| A01490-1 | BosterBio | 100ug/vial | EUR 334.00 |
 Anti-Hexokinase 1/HK1 Antibody |
|||
| A01504-1 | BosterBio | 100ug/vial | EUR 334.00 |
 Anti-Synaptotagmin 1/SYT1 Antibody |
|||
| A02314-1 | BosterBio | 100ug/vial | EUR 334.00 |
 Anti-Syntenin-1 Monoclonal Antibody |
|||
| A02475-1 | BosterBio | 100ul | EUR 397.00 |
 Anti-Dsg1/Desmoglein 1 Antibody |
|||
| A02655-1 | BosterBio | 100ul | EUR 397.00 |
 Anti-CAF-1 p150 Antibody |
|||
| A02732-1 | BosterBio | 100ul | EUR 397.00 |
 Anti-Talin 1/TLN1 Antibody |
|||
| A02859-1 | BosterBio | 100ug/vial | EUR 334.00 |
 Anti-Islet 1/ISL1 Antibody |
|||
| A02969-1 | BosterBio | 100ug/vial | EUR 334.00 |
 Anti-Relaxin 1/RLN1 Antibody |
|||
| A08367-1 | BosterBio | 100ug/vial | EUR 334.00 |
 Anti-TCP-1 zeta Antibody |
|||
| A09373-1 | BosterBio | 100ul | EUR 397.00 |
 Anti-CHST8/Galnac4St 1 Antibody |
|||
| A10989-1 | BosterBio | 100ul | EUR 397.00 |
 Anti-Musashi 1/Msi1 Antibody |
|||
| A05052-1 | BosterBio | 100ug/vial | EUR 334.00 |
 Anti-Pyrophosphatase 1/PPA1 Antibody |
|||
| A07485-1 | BosterBio | 100ug/vial | EUR 334.00 |
 Anti-TCP-1 eta Antibody |
|||
| A08169-1 | BosterBio | 100ul | EUR 397.00 |
 Anti-Dynamin 1 Monoclonal Antibody |
|||
| M02536-1 | BosterBio | 100ug | EUR 397.00 |
 Anti-Esrp-1 Monoclonal Antibody |
|||
| M06068-1 | BosterBio | 100uL | EUR 443.00 |
 Anti-Presenilin 1 Monoclonal Antibody |
|||
| M00138-1 | BosterBio | 100ug | EUR 397.00 |
 Anti-DJ-1 Monoclonal Antibody |
|||
| M00757-1 | BosterBio | 100ul | EUR 397.00 |
 Anti-Enolase 1 Monoclonal Antibody |
|||
| M01250-1 | BosterBio | 100ul | EUR 397.00 |
 Anti-Galectin 1 Monoclonal Antibody |
|||
| M00470-1 | BosterBio | 100ug | EUR 397.00 |
 Anti-Angiopoietin 1/ANGPT1 Antibody |
|||
| PA1333-1 | BosterBio | 100ug/vial | EUR 334.00 |
 Anti-Galectin 1/LGALS1 Antibody |
|||
| PB9240-1 | BosterBio | 100ug/vial | EUR 334.00 |
 Monoclonal Antibody (JSB-1)) Anti-P-glycoprotein (human) Monoclonal Antibody (JSB-1) |
|||
| M00049-1 | BosterBio | 125ug | EUR 586.00 |
 AXMIR-1 RNA oligo anti-miRNA-1-3p with Xmotif |
|||
| AXMIR-1 | SBI | 10 reactions | EUR 438.00 |
|
|||
 Anti-BOB-1/OBF-1 Rabbit Monoclonal Antibody, Clone#RM378 |
|||
| M04431-1 | BosterBio | 100uL | EUR 385.00 |
 Anti-HIF-1 alpha/HIF1A Antibody |
|||
| A00013-1 | BosterBio | 100ug/vial | EUR 294.00 |
 Antibody) Anti-Cleaved-Notch 1 (V1754) Antibody |
|||
| A00033-1 | BosterBio | 100ul | EUR 397.00 |
 Antibody) Anti-HDAC-1 (C-terminus) Antibody |
|||
| A00256-1 | BosterBio | 100uL | EUR 443.00 |
 Anti-VEGF Receptor 1/FLT1 Antibody |
|||
| A00534-1 | BosterBio | 100ug/vial | EUR 294.00 |
 Anti-Liver Carboxylesterase 1/CES1 Antibody |
|||
| A01741-1 | BosterBio | 100ug/vial | EUR 334.00 |
 Anti-EBP50/NHERF-1/SLC9A3R1 Antibody |
|||
| A02427-1 | BosterBio | 100ug/vial | EUR 334.00 |
 Anti-IL1R2/Il 1 Rii Antibody |
|||
| A03106-1 | BosterBio | 1 ml | EUR 397.00 |
 Anti-Hyaluronan synthase 1/HAS1 Antibody |
|||
| A04784-1 | BosterBio | 100ug/vial | EUR 334.00 |
 Anti-CELSR3/Flamingo Homolog 1 Antibody |
|||
| A07204-1 | BosterBio | 100ul | EUR 397.00 |
 Anti-LPCAT2/Acyltransferase Like 1 Antibody |
|||
| A07471-1 | BosterBio | 100ul | EUR 397.00 |
) Anti-Mitofusin 1 Antibody (monoclonal, 3H3) |
|||
| M02172-1 | BosterBio | 100ug/vial | EUR 294.00 |
 Anti-Cytokeratin 1 Rabbit Monoclonal Antibody |
|||
| M01639-1 | BosterBio | 100ug/vial | EUR 397.00 |
 Anti-Sumo 1 Rabbit Monoclonal Antibody |
|||
| M00631-1 | BosterBio | 100ug/vial | EUR 397.00 |
 Anti-Integrin alpha 1/ITGA1 Antibody |
|||
| PA1045-1 | BosterBio | 100ug/vial | EUR 334.00 |
- netheless remained regular. Any AGPAT2 protein produced in our affected person is due to this fact more likely to be dysfunctional. Nonetheless, formal linkage of this deletion to the neuropathy noticed stays to be proven. The classical medical presentation of a affected person with AGPAT2-associated lipodystrophy reveals regular cognition and no development of polyneuropathy. Cognitive disabilities and pol