Coagulation factor XI vaccination: an alternative strategy to prevent thrombosis.
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Essentials Coagulation Factor (F) XI is a safe target for the development of antithrombotics. We designed an antigen comprising the human FXI catalytic domain and diphtheria toxin T domain. Antigen immunization reduced plasma FXI activity by 54% and prevented thrombosis in mice. FXI vaccination can serve as an effective strategy for thrombosis prevention.
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Background Coagulation factor XI serves as a signal amplifier in the intrinsic coagulation pathway. Blockade of FXI by mAbs or small-molecule inhibitors inhibits thrombosis without causing severe bleeding, which is an inherent risk of currently available antithrombotic agents.
Coagulation Factor XII (F12) Antibody (Biotin)
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Objectives To design an FXI vaccine and assess its efficacy in inhibiting FXI activity and preventing thrombosis. Methods An FXI antigen was generated by fusing the catalytic domain of human FXI to the C-terminus of the transmembrane domain of diphtheria toxin.
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The anti-FXI antibody response, plasma FXI activity and antithrombotic efficacy in mice immunized with the FXI antigen were examined. Results The antigen elicited a significant antibody response against mouse FXI, and reduced the plasma FXI activity by 54.0% in mice. FXI vaccination markedly reduced the levels of coagulation and inflammation in a mouse model of inferior vena cava stenosis.
Mouse Coagulation Factor XII (F12) ELISA Kit
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Significant protective effects were also observed in mouse models of venous thrombosis and pulmonary embolism. Conclusions Our data demonstrate that FXI vaccination can serve as an effective strategy for thrombosis prevention.
![]() Eukaryotic Coagulation Factor XII (F12) |
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4-EPA677Mu61 | Cloud-Clone |
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![]() Coagulation Factor XII (F12) Antibody |
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20-abx111707 | Abbexa |
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![]() Coagulation Factor XII (F12) Antibody |
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20-abx001419 | Abbexa |
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![]() Coagulation Factor XII (F12) Antibody |
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20-abx102116 | Abbexa |
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![]() Coagulation Factor XII (F12) Antibody |
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20-abx102117 | Abbexa |
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![]() Coagulation Factor XII (F12) Antibody |
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abx034465-400ul | Abbexa | 400 ul | EUR 523.00 |
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![]() Coagulation Factor XII (F12) Antibody |
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abx034465-80l | Abbexa | 80 µl | EUR 286.00 |
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![]() Coagulation Factor XII (F12) Antibody |
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abx030904-400ul | Abbexa | 400 ul | EUR 523.00 |
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![]() Coagulation Factor XII (F12) Antibody |
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abx030904-80l | Abbexa | 80 µl | EUR 286.00 |
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![]() Coagulation Factor XII (F12) Antibody |
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20-abx175919 | Abbexa |
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![]() Coagulation Factor XII (F12) Antibody |
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20-abx323704 | Abbexa |
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![]() Coagulation Factor XII (F12) Antibody |
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20-abx324566 | Abbexa |
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![]() Coagulation Factor XII (F12) Antibody |
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20-abx333983 | Abbexa |
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![]() Coagulation Factor XII (F12) Antibody |
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20-abx319476 | Abbexa |
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![]() Coagulation Factor XII (F12) Antibody |
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20-abx171818 | Abbexa |
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![]() Pig Coagulation factor XII (F12) |
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1-CSB-YP007918PI | Cusabio |
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![]() Pig Coagulation factor XII (F12) |
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1-CSB-EP007918PI | Cusabio |
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![]() Recombinant Coagulation Factor XII (F12) |
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4-RPA677Hu01 | Cloud-Clone |
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![]() Recombinant Coagulation Factor XII (F12) |
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4-RPA677Mu01 | Cloud-Clone |
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![]() Human Coagulation Factor XII ELISA kit |
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E01F0027-192T | B-Gene | 192 tests | EUR 1270.00 |
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![]() Human Coagulation Factor XII ELISA kit |
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E01F0027-48 | B-Gene | 1 plate of 48 wells | EUR 520.00 |
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![]() Human Coagulation Factor XII ELISA kit |
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E01F0027-96 | B-Gene | 1 plate of 96 wells | EUR 685.00 |
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![]() Human coagulation factor XII ELISA Kit |
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ELA-E0677h | Lifescience Market | 96 Tests | EUR 824.00 |
![]() Human Coagulation Factor XII (F12) Protein |
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20-abx065987 | Abbexa |
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![]() Goat Coagulation Factor XII ELISA kit |
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E06F0027-192T | B-Gene | 192 tests | EUR 1270.00 |
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![]() Goat Coagulation Factor XII ELISA kit |
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E06F0027-48 | B-Gene | 1 plate of 48 wells | EUR 520.00 |
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![]() Goat Coagulation Factor XII ELISA kit |
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E06F0027-96 | B-Gene | 1 plate of 96 wells | EUR 685.00 |
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![]() Rat Coagulation Factor XII ELISA kit |
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E02F0027-192T | B-Gene | 192 tests | EUR 1270.00 |
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![]() Rat Coagulation Factor XII ELISA kit |
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E02F0027-48 | B-Gene | 1 plate of 48 wells | EUR 520.00 |
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![]() Rat Coagulation Factor XII ELISA kit |
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E02F0027-96 | B-Gene | 1 plate of 96 wells | EUR 685.00 |
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![]() Mouse Coagulation Factor XII ELISA kit |
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E03F0027-192T | B-Gene | 192 tests | EUR 1270.00 |
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![]() Mouse Coagulation Factor XII ELISA kit |
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E03F0027-48 | B-Gene | 1 plate of 48 wells | EUR 520.00 |
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![]() Mouse Coagulation Factor XII ELISA kit |
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E03F0027-96 | B-Gene | 1 plate of 96 wells | EUR 685.00 |
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![]() Rabbit Coagulation Factor XII ELISA kit |
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E04F0027-192T | B-Gene | 192 tests | EUR 1270.00 |
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![]() Rabbit Coagulation Factor XII ELISA kit |
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E04F0027-48 | B-Gene | 1 plate of 48 wells | EUR 520.00 |
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![]() Rabbit Coagulation Factor XII ELISA kit |
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E04F0027-96 | B-Gene | 1 plate of 96 wells | EUR 685.00 |
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![]() Dog Coagulation Factor XII ELISA kit |
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E08F0027-192T | B-Gene | 192 tests | EUR 1270.00 |
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![]() Dog Coagulation Factor XII ELISA kit |
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E08F0027-48 | B-Gene | 1 plate of 48 wells | EUR 520.00 |
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![]() Dog Coagulation Factor XII ELISA kit |
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E08F0027-96 | B-Gene | 1 plate of 96 wells | EUR 685.00 |
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![]() Monkey Coagulation Factor XII ELISA kit |
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E09F0027-192T | B-Gene | 192 tests | EUR 1270.00 |
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![]() Monkey Coagulation Factor XII ELISA kit |
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E09F0027-48 | B-Gene | 1 plate of 48 wells | EUR 520.00 |
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![]() Monkey Coagulation Factor XII ELISA kit |
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E09F0027-96 | B-Gene | 1 plate of 96 wells | EUR 685.00 |
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![]() Pig Coagulation Factor XII ELISA kit |
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E07F0027-192T | B-Gene | 192 tests | EUR 1270.00 |
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![]() Pig Coagulation Factor XII ELISA kit |
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E07F0027-48 | B-Gene | 1 plate of 48 wells | EUR 520.00 |
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![]() Pig Coagulation Factor XII ELISA kit |
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E07F0027-96 | B-Gene | 1 plate of 96 wells | EUR 685.00 |
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![]() Mouse Coagulation Factor XII (F12) Protein |
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20-abx065988 | Abbexa |
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![]() Coagulation Factor XII (F12) Antibody (HRP) |
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20-abx335142 | Abbexa |
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![]() Coagulation Factor XII (F12) Antibody (FITC) |
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20-abx335143 | Abbexa |
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![]() Coagulation Factor XII (F12) Antibody (Biotin) |
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20-abx335144 | Abbexa |
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![]() Coagulation Factor XII (F12) Antibody (HRP) |
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20-abx319477 | Abbexa |
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![]() Coagulation Factor XII (F12) Antibody (FITC) |
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20-abx319478 | Abbexa |
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![]() Coagulation Factor XII (F12) Antibody (Biotin) |
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20-abx319479 | Abbexa |
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![]() Human Coagulation Factor XII (F12) ELISA Kit |
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abx570144-96tests | Abbexa | 96 tests | EUR 668.00 |
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![]() ELISA kit for Human Coagulation factor XII |
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EK2136 | SAB | 96 tests | EUR 553.00 |
![]() Human F12/ Coagulation factor XII ELISA Kit |
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E0833Hu | Sunlong | 1 Kit | EUR 571.00 |
![]() Human F12(Coagulation factor XII) ELISA Kit |
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EH1012 | FN Test | 96T | EUR 476.25 |
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![]() Human Coagulation factor XII, F12 ELISA KIT |
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ELI-02420h | Lifescience Market | 96 Tests | EUR 824.00 |
![]() Human Coagulation Factor XII (F12) ELISA Kit |
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20-abx151465 | Abbexa |
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![]() Human Coagulation Factor XII (F12) CLIA Kit |
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abx196535-96tests | Abbexa | 96 tests | EUR 825.00 |
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![]() Human Coagulation Factor XII (F12) CLIA Kit |
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20-abx491868 | Abbexa |
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![]() Human Coagulation Factor XII (F12) ELISA Kit |
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abx250251-96tests | Abbexa | 96 tests | EUR 668.00 |
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![]() Human Coagulation Factor XII (F12) ELISA Kit |
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DLR-F12-Hu-48T | DL Develop | 48T | EUR 479.00 |
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![]() Human Coagulation Factor XII (F12) ELISA Kit |
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DLR-F12-Hu-96T | DL Develop | 96T | EUR 621.00 |
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![]() Human Coagulation factor XII(F12) ELISA kit |
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CSB-EL007918HU-24T | Cusabio | 1 plate of 24 wells | EUR 165.00 |
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![]() Human Coagulation factor XII(F12) ELISA kit |
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1-CSB-EL007918HU | Cusabio |
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![]() Coagulation Factor XII (F12) Polyclonal Antibody (Human) |
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4-PAA677Hu01 | Cloud-Clone |
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![]() Human Coagulation Factor XII (F12) ELISA Kit |
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SEA677Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 4273.35 |
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![]() Human Coagulation Factor XII (F12) ELISA Kit |
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SEA677Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 439.57 |
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![]() Human Coagulation Factor XII (F12) ELISA Kit |
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SEA677Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 585.10 |
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![]() Human Coagulation Factor XII (F12) ELISA Kit |
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SEA677Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 2332.95 |
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![]() Human Coagulation Factor XII (F12) ELISA Kit |
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4-SEA677Hu | Cloud-Clone |
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![]() Human Coagulation Factor XII (F12) ELISA Kit |
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RD-F12-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 478.00 |
![]() Human Coagulation Factor XII (F12) ELISA Kit |
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RD-F12-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 662.00 |
![]() Human Coagulation Factor XII (F12) ELISA Kit |
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RDR-F12-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 500.00 |
![]() Human Coagulation Factor XII (F12) ELISA Kit |
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RDR-F12-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 692.00 |
![]() anti- Factor XII antibody |
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FNab02938 | FN Test | 100µg | EUR 505.25 |
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![]() anti- Factor XII antibody |
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FNab02939 | FN Test | 100µg | EUR 548.75 |
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![]() Anti-Factor XII antibody |
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PAab02938 | Lifescience Market | 100 ug | EUR 355.00 |
![]() Anti-Factor XII (3A3) |
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YF-MA12927 | Abfrontier | 100 ug | EUR 363.00 |
![]() Rabbit Coagulation Factor XII (F12) ELISA Kit |
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abx362129-96tests | Abbexa | 96 tests | EUR 825.00 |
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![]() Cow Coagulation Factor XII (F12) ELISA Kit |
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abx513739-96tests | Abbexa | 96 tests | EUR 911.00 |
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![]() Rat Coagulation Factor XII (F12) ELISA Kit |
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abx513743-96tests | Abbexa | 96 tests | EUR 707.00 |
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![]() Mouse Coagulation Factor XII (F12) ELISA Kit |
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abx573343-96tests | Abbexa | 96 tests | EUR 707.00 |
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![]() Guinea pig Coagulation Factor XII ELISA kit |
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E05F0027-192T | B-Gene | 192 tests | EUR 1270.00 |
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![]() Guinea pig Coagulation Factor XII ELISA kit |
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E05F0027-48 | B-Gene | 1 plate of 48 wells | EUR 520.00 |
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![]() Guinea pig Coagulation Factor XII ELISA kit |
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E05F0027-96 | B-Gene | 1 plate of 96 wells | EUR 685.00 |
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![]() Mouse Coagulation factor XII, F12 ELISA KIT |
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ELI-02416m | Lifescience Market | 96 Tests | EUR 865.00 |
![]() Bovine Coagulation factor XII, F12 ELISA KIT |
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ELI-02417b | Lifescience Market | 96 Tests | EUR 928.00 |
![]() Porcine Coagulation factor XII, F12 ELISA KIT |
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ELI-02418p | Lifescience Market | 96 Tests | EUR 928.00 |
![]() Mouse FXII(Coagulation Factor XII) ELISA Kit |
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EM1046 | FN Test | 96T | EUR 524.10 |
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Excess of heme induces tissue factor-dependent activation of coagulation in mice.
- An excess of free heme is present in the blood during many types of hemolytic anemia. This has been linked to organ damage caused by heme-mediated oxidative stress and vascular inflammation. We investigated the mechanism of heme-induced coagulation activation in vivo.
- Heme caused coagulation activation in wild-type mice that was attenuated by an anti-tissue factor antibody and in mice expressing low levels of tissue factor. In contrast, neither factor XI deletion nor inhibition of factor XIIa-mediated factor XI activation reduced heme-induced coagulation activation, suggesting that the intrinsic coagulation pathway is not involved. We investigated the source of tissue factor in heme-induced coagulation activation.
Rat Coagulation Factor XI (F11) Protein | Coagulation Factor XI (F11) Antibody (HRP)
- Heme increased the procoagulant activity of mouse macrophages and human PBMCs. Tissue factor-positive staining was observed on leukocytes isolated from the blood of heme-treated mice but not on endothelial cells in the lungs. Furthermore, heme increased vascular permeability in the mouse lungs, kidney and heart.
- Deletion of tissue factor from either myeloid cells, hematopoietic or endothelial cells, or inhibition of tissue factor expressed by non-hematopoietic cells did not reduce heme-induced coagulation activation. However, heme-induced activation of coagulation was abolished when both non-hematopoietic and hematopoietic cell tissue factor was inhibited.
![]() Human Coagulation factor XI (F11) |
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1-CSB-EP007916HU | Cusabio |
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![]() Mouse Coagulation Factor XI ELISA kit |
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E03F0026-192T | B-Gene | 192 tests | EUR 1270.00 |
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![]() Mouse Coagulation Factor XI ELISA kit |
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E03F0026-48 | B-Gene | 1 plate of 48 wells | EUR 520.00 |
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![]() Mouse Coagulation Factor XI ELISA kit |
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E03F0026-96 | B-Gene | 1 plate of 96 wells | EUR 685.00 |
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![]() Mouse Coagulation Factor XI (F11) Protein |
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20-abx065986 | Abbexa |
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![]() Coagulation Factor XI (F11) Antibody |
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20-abx215271 | Abbexa |
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![]() Coagulation Factor XI (F11) Antibody |
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20-abx101988 | Abbexa |
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![]() Coagulation Factor XI (F11) Antibody |
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20-abx101989 | Abbexa |
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![]() Coagulation Factor XI (F11) Antibody |
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20-abx130293 | Abbexa |
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![]() Coagulation Factor XI (F11) Antibody |
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abx122726-100ug | Abbexa | 100 ug | EUR 391.00 |
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![]() Coagulation Factor XI (F11) Antibody |
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20-abx171816 | Abbexa |
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![]() Coagulation Factor XI (F11) Antibody |
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20-abx171817 | Abbexa |
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![]() Coagulation Factor XI (F11) Antibody |
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20-abx301182 | Abbexa |
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![]() Recombinant Coagulation Factor XI (F11) |
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4-RPB834Hu01 | Cloud-Clone |
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![]() Recombinant Coagulation Factor XI (F11) |
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4-RPB834Mu01 | Cloud-Clone |
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![]() Recombinant Coagulation Factor XI (F11) |
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4-RPB834Ra01 | Cloud-Clone |
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![]() Human Coagulation Factor XI ELISA kit |
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E01F0026-192T | B-Gene | 192 tests | EUR 1270.00 |
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![]() Human Coagulation Factor XI ELISA kit |
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E01F0026-48 | B-Gene | 1 plate of 48 wells | EUR 520.00 |
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![]() Human Coagulation Factor XI ELISA kit |
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E01F0026-96 | B-Gene | 1 plate of 96 wells | EUR 685.00 |
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![]() Human Coagulation Factor XI (F11) Protein |
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20-abx065983 | Abbexa |
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![]() Mouse F11/ Coagulation factor XI ELISA Kit |
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E0481Mo | Sunlong | 1 Kit | EUR 571.00 |
![]() Mouse Coagulation Factor XI (F11) ELISA Kit |
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abx254821-96tests | Abbexa | 96 tests | EUR 668.00 |
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![]() ELISA kit for Mouse Coagulation factor XI |
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EK2353 | SAB | 96 tests | EUR 553.00 |
![]() Mouse Coagulation factor XI, F11 ELISA KIT |
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ELI-02897m | Lifescience Market | 96 Tests | EUR 865.00 |
![]() Mouse F11(Coagulation factor XI) ELISA Kit |
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EM0468 | FN Test | 96T | EUR 567.60 |
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![]() Coagulation Factor XI (F11) Polyclonal Antibody (Mouse) |
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4-PAB834Mu01 | Cloud-Clone |
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![]() Mouse Coagulation Factor XI(F11)ELISA kit |
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QY-E20354 | Qayee Biotechnology | 96T | EUR 361.00 |
![]() Human Coagulation Factor XI (F11) ELISA Kit |
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DLR-F11-Hu-48T | DL Develop | 48T | EUR 498.00 |
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![]() Human Coagulation Factor XI (F11) ELISA Kit |
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DLR-F11-Hu-96T | DL Develop | 96T | EUR 647.00 |
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![]() Human Coagulation Factor XI (F11) CLIA Kit |
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abx196534-96tests | Abbexa | 96 tests | EUR 825.00 |
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![]() Human Coagulation Factor XI (F11) ELISA Kit |
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20-abx151110 | Abbexa |
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![]() Human Coagulation Factor XI (F11) ELISA Kit |
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abx250314-96tests | Abbexa | 96 tests | EUR 668.00 |
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![]() ELISA kit for Human Coagulation factor XI |
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EK2354 | SAB | 96 tests | EUR 553.00 |
![]() Human F11/ Coagulation factor XI ELISA Kit |
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E0832Hu | Sunlong | 1 Kit | EUR 571.00 |
![]() Human F11(Coagulation factor XI) ELISA Kit |
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EH1071 | FN Test | 96T | EUR 476.25 |
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![]() Human Coagulation factor XI, F11 ELISA KIT |
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ELI-02895h | Lifescience Market | 96 Tests | EUR 824.00 |
![]() Human Coagulation factor XI(F11) ELISA kit |
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CSB-EL007916HU-24T | Cusabio | 1 plate of 24 wells | EUR 165.00 |
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![]() Human Coagulation factor XI(F11) ELISA kit |
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1-CSB-EL007916HU | Cusabio |
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![]() Human Coagulation Factor XI (F11) ELISA Kit |
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abx572158-96tests | Abbexa | 96 tests | EUR 668.00 |
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![]() Human Coagulation Factor XI (F11) CLIA Kit |
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20-abx493138 | Abbexa |
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![]() Coagulation Factor XI (F11) Polyclonal Antibody (Human) |
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4-PAB834Hu01 | Cloud-Clone |
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![]() Human Coagulation Factor XI(F11)ELISA Kit |
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QY-E02020 | Qayee Biotechnology | 96T | EUR 361.00 |
![]() Human Coagulation Factor XI ELISA Kit (F11) |
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RK01336 | Abclonal | 96 Tests | EUR 521.00 |
![]() Human Coagulation Factor XI (F11) ELISA Kit |
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RDR-F11-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 522.00 |
![]() Human Coagulation Factor XI (F11) ELISA Kit |
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RDR-F11-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 724.00 |
![]() Human Coagulation Factor XI (F11) ELISA Kit |
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SEB834Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 4502.43 |
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![]() Human Coagulation Factor XI (F11) ELISA Kit |
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SEB834Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 458.44 |
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![]() Human Coagulation Factor XI (F11) ELISA Kit |
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SEB834Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 612.05 |
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![]() Human Coagulation Factor XI (F11) ELISA Kit |
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SEB834Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 2454.23 |
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![]() Human Coagulation Factor XI (F11) ELISA Kit |
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4-SEB834Hu | Cloud-Clone |
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![]() Human Coagulation Factor XI (F11) ELISA Kit |
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RD-F11-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 500.00 |
![]() Human Coagulation Factor XI (F11) ELISA Kit |
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RD-F11-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 692.00 |
![]() Rat Coagulation Factor XI ELISA kit |
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E02F0026-192T | B-Gene | 192 tests | EUR 1270.00 |
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![]() Rat Coagulation Factor XI ELISA kit |
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E02F0026-48 | B-Gene | 1 plate of 48 wells | EUR 520.00 |
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![]() Rat Coagulation Factor XI ELISA kit |
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E02F0026-96 | B-Gene | 1 plate of 96 wells | EUR 685.00 |
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![]() Goat Coagulation Factor XI ELISA kit |
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E06F0026-192T | B-Gene | 192 tests | EUR 1270.00 |
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![]() Goat Coagulation Factor XI ELISA kit |
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E06F0026-48 | B-Gene | 1 plate of 48 wells | EUR 520.00 |
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![]() Goat Coagulation Factor XI ELISA kit |
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E06F0026-96 | B-Gene | 1 plate of 96 wells | EUR 685.00 |
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![]() Rabbit Coagulation Factor XI ELISA kit |
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E04F0026-192T | B-Gene | 192 tests | EUR 1270.00 |
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![]() Rabbit Coagulation Factor XI ELISA kit |
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E04F0026-48 | B-Gene | 1 plate of 48 wells | EUR 520.00 |
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- Finally, we demonstrated that coagulation activation was partially attenuated in sickle cell mice treated with recombinant hemopexin to neutralize free heme. Our results indicate that heme promotes tissue factor-dependent coagulation activation and induces tissue factor expression on leukocytes in vivo. We also demonstrated that free heme may contribute to thrombin generation in a mouse model of sickle cell disease.
- We demonstrate that transduction of adipocytes with a simian immunodeficiency virus agm TYO1 (SIVagm)-based lentiviral vector carrying the human coagulation factor VIII gene (SIVhFVIII) resulted in expression of the human FVIII transgene in vitro and in db/db mice in vivo. Cultured human adipocytes were transduced with the SIVagm vector carrying the GFP gene in a dose-dependent manner and transduction of adipocytes with SIVhFVIII resulted in efficient expression of human coagulation factor VIII (hFVIII; 320 +/- 39.8 ng/10(6) adipocytes/24 h) in vitro. Based upon success