Coagulation factor XI vaccination: an alternative strategy to prevent thrombosis.

 

• Essentials Coagulation Factor (F) XI is a safe target for the development of antithrombotics. We designed an antigen comprising the human FXI catalytic domain and diphtheria toxin T domain. Antigen immunization reduced plasma FXI activity by 54% and prevented thrombosis in mice. FXI vaccination can serve as an effective strategy for thrombosis prevention.

 

• Background Coagulation factor XI serves as a signal amplifier in the intrinsic coagulation pathway. Blockade of FXI by mAbs or small-molecule inhibitors inhibits thrombosis without causing severe bleeding, which is an inherent risk of currently available antithrombotic agents.

          Coagulation Factor XII (F12) Antibody (Biotin)

• Objectives To design an FXI vaccine and assess its efficacy in inhibiting FXI activity and preventing thrombosis. Methods An FXI antigen was generated by fusing the catalytic domain of human FXI to the C-terminus of the transmembrane domain of diphtheria toxin.

 

• The anti-FXI antibody response, plasma FXI activity and antithrombotic efficacy in mice immunized with the FXI antigen were examined. Results The antigen elicited a significant antibody response against mouse FXI, and reduced the plasma FXI activity by 54.0% in mice. FXI vaccination markedly reduced the levels of coagulation and inflammation in a mouse model of inferior vena cava stenosis.

       Mouse Coagulation Factor XII (F12) ELISA Kit

• Significant protective effects were also observed in mouse models of venous thrombosis and pulmonary embolism. Conclusions Our data demonstrate that FXI vaccination can serve as an effective strategy for thrombosis prevention.

Pig Coagulation factor XII (F12)
1-CSB-YP007918PI	Cusabio	EUR 679.00 EUR 335.00 EUR 2172.00 EUR 1051.00 EUR 1442.00 EUR 435.00	100ug 10ug 1MG 200ug 500ug 50ug

Recombinant Coagulation Factor XII (F12)
4-RPA677Hu01	Cloud-Clone	EUR 512.16 EUR 240.00 EUR 1645.60 EUR 615.20 EUR 1130.40 EUR 406.00 EUR 3964.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg

Recombinant Coagulation Factor XII (F12)
4-RPA677Mu01	Cloud-Clone	EUR 485.28 EUR 233.00 EUR 1544.80 EUR 581.60 EUR 1063.20 EUR 388.00 EUR 3712.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg

Pig Coagulation factor XII (F12)
1-CSB-EP007918PI	Cusabio	EUR 611.00 EUR 309.00 EUR 1827.00 EUR 939.00 EUR 1218.00 EUR 397.00	100ug 10ug 1MG 200ug 500ug 50ug

Eukaryotic Coagulation Factor XII (F12)
4-EPA677Mu61	Cloud-Clone	EUR 413.60 EUR 214.00 EUR 1276.00 EUR 492.00 EUR 884.00 EUR 340.00 EUR 3040.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg

Coagulation Factor XII (F12) Antibody
20-abx111707	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Coagulation Factor XII (F12) Antibody
20-abx319476	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Coagulation Factor XII (F12) Antibody
20-abx323704	Abbexa	EUR 314.00 EUR 244.00	100 ug 50 ug

Coagulation Factor XII (F12) Antibody
20-abx175919	Abbexa	EUR 411.00 EUR 133.00 EUR 1135.00 EUR 551.00 EUR 314.00	100 ug 10 ug 1 mg 200 ug 50 ug

Coagulation Factor XII (F12) Antibody
20-abx171818	Abbexa	EUR 787.00 EUR 411.00	1 mg 200 ug

Coagulation Factor XII (F12) Antibody
20-abx324566	Abbexa	EUR 314.00 EUR 244.00	100 ug 50 ug

Coagulation Factor XII (F12) Antibody
20-abx333983	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Coagulation Factor XII (F12) Antibody
20-abx001419	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

Coagulation Factor XII (F12) Antibody
20-abx102116	Abbexa	EUR 398.00 EUR 133.00 EUR 1107.00 EUR 537.00 EUR 314.00	100 ug 10 ug 1 mg 200 ug 50 ug

Coagulation Factor XII (F12) Antibody
20-abx102117	Abbexa	EUR 411.00 EUR 133.00 EUR 1135.00 EUR 551.00 EUR 314.00	100 ug 10 ug 1 mg 200 ug 50 ug

Coagulation Factor XII (F12) Antibody
abx034465-400ul	Abbexa	400 ul	EUR 523

Coagulation Factor XII (F12) Antibody
abx034465-80l	Abbexa	80 µl	EUR 286

Coagulation Factor XII (F12) Antibody
abx030904-400ul	Abbexa	400 ul	EUR 523

Coagulation Factor XII (F12) Antibody
abx030904-80l	Abbexa	80 µl	EUR 286

Human coagulation factor XII ELISA Kit
ELA-E0677h	Lifescience Market	96 Tests	EUR 824

Human Coagulation Factor XII ELISA kit
E01F0027-192T	BlueGene	192 tests	EUR 1270

Human Coagulation Factor XII ELISA kit
E01F0027-48	BlueGene	1 plate of 48 wells	EUR 520

Human Coagulation Factor XII ELISA kit
E01F0027-96	BlueGene	1 plate of 96 wells	EUR 685

Human Coagulation Factor XII (F12) Protein
20-abx065987	Abbexa	EUR 718.00 EUR 286.00 EUR 2221.00 EUR 857.00 EUR 509.00	100 ug 10 ug 1 mg 200 ug 50 ug

Mouse Coagulation Factor XII ELISA kit
E03F0027-192T	BlueGene	192 tests	EUR 1270

Mouse Coagulation Factor XII ELISA kit
E03F0027-48	BlueGene	1 plate of 48 wells	EUR 520

Mouse Coagulation Factor XII ELISA kit
E03F0027-96	BlueGene	1 plate of 96 wells	EUR 685

Rat Coagulation Factor XII ELISA kit
E02F0027-192T	BlueGene	192 tests	EUR 1270

Rat Coagulation Factor XII ELISA kit
E02F0027-48	BlueGene	1 plate of 48 wells	EUR 520

Rat Coagulation Factor XII ELISA kit
E02F0027-96	BlueGene	1 plate of 96 wells	EUR 685

Monkey Coagulation Factor XII ELISA kit
E09F0027-192T	BlueGene	192 tests	EUR 1270

Monkey Coagulation Factor XII ELISA kit
E09F0027-48	BlueGene	1 plate of 48 wells	EUR 520

Monkey Coagulation Factor XII ELISA kit
E09F0027-96	BlueGene	1 plate of 96 wells	EUR 685

Dog Coagulation Factor XII ELISA kit
E08F0027-192T	BlueGene	192 tests	EUR 1270

Dog Coagulation Factor XII ELISA kit
E08F0027-48	BlueGene	1 plate of 48 wells	EUR 520

Dog Coagulation Factor XII ELISA kit
E08F0027-96	BlueGene	1 plate of 96 wells	EUR 685

Pig Coagulation Factor XII ELISA kit
E07F0027-192T	BlueGene	192 tests	EUR 1270

Pig Coagulation Factor XII ELISA kit
E07F0027-48	BlueGene	1 plate of 48 wells	EUR 520

Pig Coagulation Factor XII ELISA kit
E07F0027-96	BlueGene	1 plate of 96 wells	EUR 685

Rabbit Coagulation Factor XII ELISA kit
E04F0027-192T	BlueGene	192 tests	EUR 1270

Rabbit Coagulation Factor XII ELISA kit
E04F0027-48	BlueGene	1 plate of 48 wells	EUR 520

Rabbit Coagulation Factor XII ELISA kit
E04F0027-96	BlueGene	1 plate of 96 wells	EUR 685

Goat Coagulation Factor XII ELISA kit
E06F0027-192T	BlueGene	192 tests	EUR 1270

Goat Coagulation Factor XII ELISA kit
E06F0027-48	BlueGene	1 plate of 48 wells	EUR 520

Goat Coagulation Factor XII ELISA kit
E06F0027-96	BlueGene	1 plate of 96 wells	EUR 685

Coagulation Factor XII (F12) Antibody (HRP)
20-abx319477	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Coagulation Factor XII (F12) Antibody (FITC)
20-abx319478	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Coagulation Factor XII (F12) Antibody (Biotin)
20-abx319479	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Coagulation Factor XII (F12) Antibody (HRP)
20-abx335142	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Coagulation Factor XII (F12) Antibody (FITC)
20-abx335143	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Coagulation Factor XII (F12) Antibody (Biotin)
20-abx335144	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Mouse Coagulation Factor XII (F12) Protein
20-abx065988	Abbexa	EUR 676.00 EUR 286.00 EUR 2082.00 EUR 801.00 EUR 481.00	100 ug 10 ug 1 mg 200 ug 50 ug

Human Coagulation factor XII, F12 ELISA KIT
ELI-02420h	Lifescience Market	96 Tests	EUR 824

Human Coagulation Factor XII (F12) ELISA Kit
SEA677Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 4273.35

Human Coagulation Factor XII (F12) ELISA Kit
SEA677Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 439.57

Human Coagulation Factor XII (F12) ELISA Kit
SEA677Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 585.1

Human Coagulation Factor XII (F12) ELISA Kit
SEA677Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 2332.95

Human Coagulation Factor XII (F12) ELISA Kit
4-SEA677Hu	Cloud-Clone	EUR 4324.00 EUR 2283.00 EUR 586.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells

Coagulation Factor XII (F12) Polyclonal Antibody (Human)
4-PAA677Hu01	Cloud-Clone	EUR 232.00 EUR 2285.00 EUR 574.00 EUR 289.00 EUR 208.00	100ul 10ml 1ml 200ul 20ul

Human Coagulation factor XII(F12) ELISA kit
CSB-EL007918HU-24T	Cusabio	1 plate of 24 wells	EUR 165

Human Coagulation factor XII(F12) ELISA kit
1-CSB-EL007918HU	Cusabio	EUR 703.00 EUR 4843.00 EUR 2570.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each

Human Coagulation Factor XII (F12) ELISA Kit
abx570144-96tests	Abbexa	96 tests	EUR 668

Human Coagulation Factor XII (F12) CLIA Kit
20-abx491868	Abbexa	EUR 7973.00 EUR 4246.00 EUR 981.00	10 × 96 tests 5 × 96 tests 96 tests

Human Coagulation Factor XII (F12) CLIA Kit
abx196535-96tests	Abbexa	96 tests	EUR 825

Human Coagulation Factor XII (F12) ELISA Kit
abx250251-96tests	Abbexa	96 tests	EUR 668

Human Coagulation Factor XII (F12) ELISA Kit
20-abx151465	Abbexa	EUR 6642.00 EUR 3542.00 EUR 825.00	10 × 96 tests 5 × 96 tests 96 tests

Human Coagulation Factor XII (F12) ELISA Kit
DLR-F12-Hu-48T	DL Develop	48T	EUR 479

Human Coagulation Factor XII (F12) ELISA Kit
DLR-F12-Hu-96T	DL Develop	96T	EUR 621

Human Coagulation Factor XII (F12) ELISA Kit
RD-F12-Hu-48Tests	Reddot Biotech	48 Tests	EUR 478

Human Coagulation Factor XII (F12) ELISA Kit
RD-F12-Hu-96Tests	Reddot Biotech	96 Tests	EUR 662

Human F12/ Coagulation factor XII ELISA Kit
E0833Hu	Sunlong	1 Kit	EUR 571

Human Coagulation Factor XII (F12) ELISA Kit
RDR-F12-Hu-48Tests	Reddot Biotech	48 Tests	EUR 500

Human Coagulation Factor XII (F12) ELISA Kit
RDR-F12-Hu-96Tests	Reddot Biotech	96 Tests	EUR 692

ELISA kit for Human Coagulation factor XII
EK2136	SAB	96 tests	EUR 553

Human F12(Coagulation factor XII) ELISA Kit
EH1012	FN Test	96T	EUR 476.25

Anti-Factor XII (3A3)
YF-MA12927	Abfrontier	100 ug	EUR 363

Anti-Factor XII antibody
PAab02938	Lifescience Market	100 ug	EUR 355

anti- Factor XII antibody
FNab02938	FN Test	100µg	EUR 505.25

anti- Factor XII antibody
FNab02939	FN Test	100µg	EUR 548.75

Mouse Coagulation factor XII, F12 ELISA KIT
ELI-02416m	Lifescience Market	96 Tests	EUR 865

Bovine Coagulation factor XII, F12 ELISA KIT
ELI-02417b	Lifescience Market	96 Tests	EUR 928

Porcine Coagulation factor XII, F12 ELISA KIT
ELI-02418p	Lifescience Market	96 Tests	EUR 928

Mouse Coagulation Factor XII (F12) ELISA Kit
SEA677Mu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 4391.16

Mouse Coagulation Factor XII (F12) ELISA Kit
SEA677Mu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 449.27

Mouse Coagulation Factor XII (F12) ELISA Kit
SEA677Mu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 598.96

Mouse Coagulation Factor XII (F12) ELISA Kit
SEA677Mu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 2395.32

Mouse Coagulation Factor XII (F12) ELISA Kit
4-SEA677Mu	Cloud-Clone	EUR 4442.00 EUR 2346.00 EUR 599.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells

Coagulation Factor XII (F12) Polyclonal Antibody (Mouse)
4-PAA677Mu01	Cloud-Clone	EUR 236.00 EUR 2338.00 EUR 586.00 EUR 294.00 EUR 209.00	100ul 10ml 1ml 200ul 20ul

Guinea pig Coagulation Factor XII ELISA kit
E05F0027-192T	BlueGene	192 tests	EUR 1270

Guinea pig Coagulation Factor XII ELISA kit
E05F0027-48	BlueGene	1 plate of 48 wells	EUR 520

Excess of heme induces tissue factor-dependent activation of coagulation in mice.

 

• An excess of free heme is present in the blood during many types of hemolytic anemia. This has been linked to organ damage caused by heme-mediated oxidative stress and vascular inflammation. We investigated the mechanism of heme-induced coagulation activation in vivo.

 

• Heme caused coagulation activation in wild-type mice that was attenuated by an anti-tissue factor antibody and in mice expressing low levels of tissue factor. In contrast, neither factor XI deletion nor inhibition of factor XIIa-mediated factor XI activation reduced heme-induced coagulation activation, suggesting that the intrinsic coagulation pathway is not involved. We investigated the source of tissue factor in heme-induced coagulation activation.

       Rat Coagulation Factor XI (F11) Protein | Coagulation Factor XI (F11) Antibody (HRP)

• Heme increased the procoagulant activity of mouse macrophages and human PBMCs. Tissue factor-positive staining was observed on leukocytes isolated from the blood of heme-treated mice but not on endothelial cells in the lungs. Furthermore, heme increased vascular permeability in the mouse lungs, kidney and heart.

 

• Deletion of tissue factor from either myeloid cells, hematopoietic or endothelial cells, or inhibition of tissue factor expressed by non-hematopoietic cells did not reduce heme-induced coagulation activation. However, heme-induced activation of coagulation was abolished when both non-hematopoietic and hematopoietic cell tissue factor was inhibited.

Human Coagulation factor XI (F11)
1-CSB-EP007916HU	Cusabio	EUR 505.00 EUR 265.00 EUR 1827.00 EUR 766.00 EUR 1218.00 EUR 335.00	100ug 10ug 1MG 200ug 500ug 50ug

Mouse Coagulation Factor XI ELISA kit
E03F0026-192T	BlueGene	192 tests	EUR 1270

Mouse Coagulation Factor XI ELISA kit
E03F0026-48	BlueGene	1 plate of 48 wells	EUR 520

Mouse Coagulation Factor XI ELISA kit
E03F0026-96	BlueGene	1 plate of 96 wells	EUR 685

Mouse Coagulation Factor XI (F11) Protein
20-abx065986	Abbexa	EUR 578.00 EUR 258.00 EUR 1720.00 EUR 690.00 EUR 425.00	100 ug 10 ug 1 mg 200 ug 50 ug

Human Coagulation Factor XI ELISA kit
E01F0026-192T	BlueGene	192 tests	EUR 1270

Human Coagulation Factor XI ELISA kit
E01F0026-48	BlueGene	1 plate of 48 wells	EUR 520

Human Coagulation Factor XI ELISA kit
E01F0026-96	BlueGene	1 plate of 96 wells	EUR 685

Human Coagulation Factor XI (F11) Protein
20-abx065983	Abbexa	EUR 690.00 EUR 286.00 EUR 2124.00 EUR 815.00 EUR 495.00	100 ug 10 ug 1 mg 200 ug 50 ug

Recombinant Coagulation Factor XI (F11)
4-RPB834Hu01	Cloud-Clone	EUR 494.24 EUR 235.00 EUR 1578.40 EUR 592.80 EUR 1085.60 EUR 394.00 EUR 3796.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg

Recombinant Coagulation Factor XI (F11)
4-RPB834Mu01	Cloud-Clone	EUR 413.60 EUR 214.00 EUR 1276.00 EUR 492.00 EUR 884.00 EUR 340.00 EUR 3040.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg

Recombinant Coagulation Factor XI (F11)
4-RPB834Ra01	Cloud-Clone	EUR 548.00 EUR 250.00 EUR 1780.00 EUR 660.00 EUR 1220.00 EUR 430.00 EUR 4300.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg

Coagulation Factor XI (F11) Antibody
20-abx130293	Abbexa	EUR 439.00 EUR 133.00 EUR 1247.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

Coagulation Factor XI (F11) Antibody
abx122726-100ug	Abbexa	100 ug	EUR 391

Coagulation Factor XI (F11) Antibody
20-abx215271	Abbexa	EUR 425.00 EUR 342.00	100 ug 50 ug

Coagulation Factor XI (F11) Antibody
20-abx171816	Abbexa	EUR 815.00 EUR 425.00	1 mg 200 ug

Coagulation Factor XI (F11) Antibody
20-abx171817	Abbexa	EUR 871.00 EUR 453.00	1 mg 200 ug

Coagulation Factor XI (F11) Antibody
20-abx301182	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Coagulation Factor XI (F11) Antibody
20-abx101988	Abbexa	EUR 411.00 EUR 133.00 EUR 1149.00 EUR 565.00 EUR 314.00	100 ug 10 ug 1 mg 200 ug 50 ug

Coagulation Factor XI (F11) Antibody
20-abx101989	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

Mouse Coagulation factor XI, F11 ELISA KIT
ELI-02897m	Lifescience Market	96 Tests	EUR 865

Coagulation Factor XI (F11) Polyclonal Antibody (Mouse)
4-PAB834Mu01	Cloud-Clone	EUR 251.00 EUR 2576.00 EUR 640.00 EUR 316.00 EUR 215.00	100ul 10ml 1ml 200ul 20ul

Mouse Coagulation Factor XI (F11) ELISA Kit
abx254821-96tests	Abbexa	96 tests	EUR 668

Mouse F11/ Coagulation factor XI ELISA Kit
E0481Mo	Sunlong	1 Kit	EUR 571

ELISA kit for Mouse Coagulation factor XI
EK2353	SAB	96 tests	EUR 553

Mouse F11(Coagulation factor XI) ELISA Kit
EM0468	FN Test	96T	EUR 567.6

Mouse Coagulation Factor XI(F11)ELISA kit
QY-E20354	Qayee Biotechnology	96T	EUR 361

Human Coagulation factor XI, F11 ELISA KIT
ELI-02895h	Lifescience Market	96 Tests	EUR 824

Human Coagulation Factor XI (F11) ELISA Kit
SEB834Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 4502.43

Human Coagulation Factor XI (F11) ELISA Kit
SEB834Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 458.44

Human Coagulation Factor XI (F11) ELISA Kit
SEB834Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 612.05

Human Coagulation Factor XI (F11) ELISA Kit
SEB834Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 2454.23

Human Coagulation Factor XI (F11) ELISA Kit
4-SEB834Hu	Cloud-Clone	EUR 4553.00 EUR 2405.00 EUR 613.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells

Coagulation Factor XI (F11) Polyclonal Antibody (Human)
4-PAB834Hu01	Cloud-Clone	EUR 239.00 EUR 2391.00 EUR 598.00 EUR 299.00 EUR 211.00	100ul 10ml 1ml 200ul 20ul

Human Coagulation factor XI(F11) ELISA kit
CSB-EL007916HU-24T	Cusabio	1 plate of 24 wells	EUR 165

Human Coagulation factor XI(F11) ELISA kit
1-CSB-EL007916HU	Cusabio	EUR 804.00 EUR 5099.00 EUR 2704.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each

Human Coagulation Factor XI (F11) ELISA Kit
abx572158-96tests	Abbexa	96 tests	EUR 668

Human Coagulation Factor XI (F11) CLIA Kit
20-abx493138	Abbexa	EUR 7973.00 EUR 4246.00 EUR 981.00	10 × 96 tests 5 × 96 tests 96 tests

Human Coagulation Factor XI (F11) CLIA Kit
abx196534-96tests	Abbexa	96 tests	EUR 825

Human Coagulation Factor XI (F11) ELISA Kit
abx250314-96tests	Abbexa	96 tests	EUR 668

Human Coagulation Factor XI (F11) ELISA Kit
20-abx151110	Abbexa	EUR 7112.00 EUR 3792.00 EUR 879.00	10 × 96 tests 5 × 96 tests 96 tests

Human Coagulation Factor XI (F11) ELISA Kit
DLR-F11-Hu-48T	DL Develop	48T	EUR 498

Human Coagulation Factor XI (F11) ELISA Kit
DLR-F11-Hu-96T	DL Develop	96T	EUR 647

Human Coagulation Factor XI (F11) ELISA Kit
RD-F11-Hu-48Tests	Reddot Biotech	48 Tests	EUR 500

Human Coagulation Factor XI (F11) ELISA Kit
RD-F11-Hu-96Tests	Reddot Biotech	96 Tests	EUR 692

Human F11/ Coagulation factor XI ELISA Kit
E0832Hu	Sunlong	1 Kit	EUR 571

Human Coagulation Factor XI ELISA Kit (F11)
RK01336	Abclonal	96 Tests	EUR 521

Human Coagulation Factor XI (F11) ELISA Kit
RDR-F11-Hu-48Tests	Reddot Biotech	48 Tests	EUR 522

Human Coagulation Factor XI (F11) ELISA Kit
RDR-F11-Hu-96Tests	Reddot Biotech	96 Tests	EUR 724

ELISA kit for Human Coagulation factor XI
EK2354	SAB	96 tests	EUR 553

Human F11(Coagulation factor XI) ELISA Kit
EH1071	FN Test	96T	EUR 476.25

Human Coagulation Factor XI(F11)ELISA Kit
QY-E02020	Qayee Biotechnology	96T	EUR 361

Rat Coagulation Factor XI ELISA kit
E02F0026-192T	BlueGene	192 tests	EUR 1270

Rat Coagulation Factor XI ELISA kit
E02F0026-48	BlueGene	1 plate of 48 wells	EUR 520

Rat Coagulation Factor XI ELISA kit
E02F0026-96	BlueGene	1 plate of 96 wells	EUR 685

Monkey Coagulation Factor XI ELISA kit
E09F0026-192T	BlueGene	192 tests	EUR 1270

Monkey Coagulation Factor XI ELISA kit
E09F0026-48	BlueGene	1 plate of 48 wells	EUR 520

Monkey Coagulation Factor XI ELISA kit
E09F0026-96	BlueGene	1 plate of 96 wells	EUR 685

Dog Coagulation Factor XI ELISA kit
E08F0026-192T	BlueGene	192 tests	EUR 1270

Dog Coagulation Factor XI ELISA kit
E08F0026-48	BlueGene	1 plate of 48 wells	EUR 520

• Finally, we demonstrated that coagulation activation was partially attenuated in sickle cell mice treated with recombinant hemopexin to neutralize free heme. Our results indicate that heme promotes tissue factor-dependent coagulation activation and induces tissue factor expression on leukocytes in vivo. We also demonstrated that free heme may contribute to thrombin generation in a mouse model of sickle cell disease.

 

• We demonstrate that transduction of adipocytes with a simian immunodeficiency virus agm TYO1 (SIVagm)-based lentiviral vector carrying the human coagulation factor VIII gene (SIVhFVIII) resulted in expression of the human FVIII transgene in vitro and in db/db mice in vivo. Cultured human adipocytes were transduced with the SIVagm vector carrying the GFP gene in a dose-dependent manner and transduction of adipocytes with SIVhFVIII resulted in efficient expression of human coagulation factor VIII (hFVIII; 320 +/- 39.8 ng/10(6) adipocytes/24 h) in vitro. Based upon success